Re: Micotoxinas y fertilidad

Toxicology 2001 May 21;162(3):209-18

Protective role of ascorbic acid to enhance semen quality of rabbits treated with sublethal doses of aflatoxin B(1).

Salem MH, Kamel KI, Yousef MI, Hassan GA, EL-Nouty FD.

Department of Animal Production, Faculty of Agriculture, El-Shatby, Alexandria University, Alexandria, Egypt.

"Aflatoxins are toxic to a wide variety of animals, including man. The antioxidant ascorbic acid (AA) plays an important role in various physiological processes in the body including detoxification of different toxic compounds. The objective of this study was to evaluate the effects of AA on productive and reproductive characteristics of mature male rabbits given two sublethal doses (15 or 30 microg/kg of body weight; every other day) of aflatoxin B(1) (AFB(1)). The experiment lasted 18 weeks and included two periods: a treatment period (first 9 weeks) where the animals were given the tested materials, and a recovery period (second 9 weeks) where all the drugs were withdrawn. Results showed that live body weight (LBW), dry matter intake (DMI), relative testes weight (RTW), and serum testosterone were significantly reduced (P<0.05) by treatment with AFB(1) in a dose-dependent manner, and these effects continued during the recovery period. Aflatoxin treatment also decreased (P<0.05) ejaculate volume, sperm concentration, total sperm output, sperm motility index, and semen initial fructose concentration. The negative effects of aflatoxin on semen characteristics were dose-dependent and continued during the recovery period. Treatment with AA increased (P<0.05) LBW, DMI, RTW, serum testosterone concentration, improved semen characteristics, and alleviated the negative effects of AFB(1). Aflatoxin treatment increased (P<0.05) the numbers of abnormal and dead sperms in a dose-dependent manner, and this effect continued during the recovery period. Treatment with AA alleviated the negative effects of AFB1 during treatment and recovery periods. Results demonstrated the beneficial influences of AA in reducing the negative effects of AFB(1) on production and reproduction of male rabbits".

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Re: Micotoxinas y fertilidad

Poult Sci 1981 Dec;60(12):2701-8
Decreased reproductive potential and reduced feed consumption in mature white leghorn males fed aflatoxin.

Sharlin JS, Howarth B Jr, Thompson FN, Wyatt RD.

"A pair-feeding study was conducted to investigate the relative importance of ingestion of aflatoxin (20 microgram/g diet) versus decreased feed consumption in explaining the effects of dietary aflatoxin on reproduction. Fifty-eight mature White Leghorn males were divided among three groups - control, 0 microgram/g diet ad lib; aflatoxin, 20 micrograms/g diet ad lib; and pair-fed, 0 microgram/g diet pair fed to 20 micrograms/g group. Aflatoxin and pair-fed males consumed significantly less feed than controls during weeks 1 through 5 of the 8-week aflatoxin feeding period. Measures of reproductive potential (semen volume, testes weights, spermatocrit, and plasma testosterone) for pair-fed males were not significantly different from males fed aflatoxin, although both groups were significantly lower than control males. Measures of aflatoxicosis (liver weight, liver fat, and plasma albumin) for pair-fed males were not significantly different from control males, although both groups were significantly different from males fed aflatoxin. In conclusion, decreased feed consumption did not produce symptoms of aflatoxicosis but accounted for 60% of the effects of aflatoxin on reproduction. Therefore, aflatoxin has nutritional and toxicological effects on reproduction".

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