LEVET PLUS
DESCRIPTION
Levamisole and chlosantel in oral and injectable solution.
TECHNICAL PROPERTIES
LEVET PLUS is an association between levamisole and chlosantel with activity against internal and external parasites.
Levogir form of tetramisol is called levamisole. It possesses antiparasitic activity. It is quickly absorbed with parenteral and oral administration. Orally, maximum blood concentration is achieved after one hour. It is recommended for the treatment of both digestive and respiratory parasites. The antiparasitic activity is due to the stimulation of the nematodes ganglions, causing neuromuscular paralysis. It therefore acts on the adult parasite but is not an ovicide.
Chlosantel is an organic endo-ecto-antiparasitic that inhibits the oxidative mitochondrial phosphorilations affecting both the adult and young forms of parasites. This inhibition causes a decrease in the synthesis of ATP, thus decreasing the metabolic activity. It is absorbed obtaining plasma concentrations of 55 ug/ml 24 hours after administration at doses of 10 mg/k.l.w. The half life of chlosantel is 15 days. The long persistence of chlosantel in the organism is due to its high capacity to fix to plasma proteins which is responsible for its long-term effect to prevent infestations and reinfestations.
INDICATIONS AND SPECIES
It is intended for the treatment of parasitosis caused by the following parasites which depend on the species:
- Ruminants: digestive strongiles (Haemonchus, Trichostrongylus, Cooperia, Nematodirus,Chabertia, Oesophagostomum, Ostertagia, Bunostomum, Fasciola, Hypoderma, Dermatobia, Boophilus, Melophagus, Psoroptes, Oestrus and Strongilus), respiratory strongiles (Dyctiocaulus) and Ascaris. external parasites as Sarcoptex, Dermatophilus, Demodex and Dermacentor.
- Pigs: digestive and respiratory strongiles, external parasites such as Sarcoptex, Demodex and Dermacentor and Ascaris - Poultry: Capilaria, Heterakis and Ascaris.
ENGOREPROD 471-2488 20080516
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